Genetic variations in thyroid cancer, called SNPs, can help diagnose, predict outcomes, and develop personalized treatments for patients with this common endocrine tumor.
Salvia miltiorrhiza Bunge, a Chinese medicinal herb known for invigorating blood circulation, has shown promising results in treating cancer. Inspired by traditional Chinese medicine, this study highlights the potential of Salvia miltiorrhiza as an effective treatment option. Its significant role in combating cancer makes it a valuable addition to the field of medicine.
This study investigated the impact of Stellera chamaejasme extract (SCE) on multidrug resistance in breast cancer. They used two cell lines, one sensitive to chemotherapy and one resistant. The results showed that SCE significantly inhibited the proliferation of both cell lines and reduced drug resistance. Moreover, SCE induced apoptosis in the cells, as evidenced by nuclear changes and increased apoptotic cell proportions. Additionally, SCE promoted autophagy and altered the expression of proteins related to apoptosis and cell cycle regulation. These findings suggest that SCE may be effective in combating drug resistance in breast cancer cells.
This study explores the relationship between traditional Chinese herbal medicine (CHM) and the survival rate in breast cancer patients, specifically those diagnosed with stage IV. While CHM has shown promise in improving survival rates and quality of life for metastatic cancer patients, little research has been done on its effects in stage IV breast cancer. This research aims to fill that gap and contribute to the growing field of personalized medicine by examining the association between CHM and survival rates in different stages of breast cancer.
Propolis, a honeybee product, is gaining attention as a potential antioxidant. Reactive oxygen species (ROS) are harmful to cells and are associated with diseases like cancer. Propolis has been shown to protect against oxidative stress and has anticancer effects. This research highlights the importance of finding exogenous antioxidants from dietary sources to combat ROS and prevent diseases.
Purple carnation flowers have been found to have the highest antioxidant and anticancer activities compared to other colors. Through a metabolomics analysis, 932 metabolites were identified and categorized, with several flavonoids, organic acids, phenolic acids, and nucleotides found as specific differential metabolites in purple flowers. Further analysis revealed that 6-hydroxykaempferol-3,6--diglucoside, 6-hydroxykaempferol-7--glucoside, quercetin-3--sophoroside, and 2'-deoxyguanosine were the major constituents responsible for the antioxidant and anticancer activities. Additionally, 2'-deoxyguanosine showed effective antiproliferative activity against certain cancer cells, and its combination with other compounds further enhanced its antitumor activity. These findings expand our knowledge of carnation's phytochemical composition and offer potential for improving the quality of carnation flowers.
Baicalin, found in Scutellaria baicalensis Georgi plant, has been shown to have kidney-protective properties. However, its impact on mesangial proliferative glomerulonephritis (MPGN) is not well understood. This study aimed to explore the effect of Baicalin on MPGN and uncover the mechanisms involved. By understanding how Baicalin affects MPGN, we can potentially develop new therapies for this prevalent form of primary glomerulonephritis.
Sophora flavescens is a traditional treatment for NSCLC, but the active compounds are not well understood. Previous research suggests that common alkaloids in the plant are only effective at high concentrations. This study aims to identify the key antitumor alkaloids in S. flavescens. This research is important as it could lead to the discovery of novel compounds for more efficient NSCLC treatment options.