Lichen-Derived Compounds and Extracts as Biologically Active Substances with Anticancer and Neuroprotective Properties.

Researchers studied the potential of extracts from four types of lichens, including their major secondary metabolites, as therapies for central nervous system diseases, particularly glioblastoma multiforme (GBM). They standardized the extracts and metabolites and tested their anti-tumor activity, anti-inflammatory properties, antioxidant activity, and anti-cholinesterase activity. The results showed that lichen-derived compounds have significant cytotoxicity against GBM cells, ability to inhibit certain enzymes, and positive anti-inflammatory properties. Additionally, some compounds can cross the blood-brain barrier, making them suitable for CNS treatment, particularly in GBM.

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