Cancer Studies

Targeting STAT3 signaling pathway by curcumin and its analogues for breast cancer: A narrative review.

Researchers studied the impact of curcumin on the STAT3 signaling pathway in breast cancer, showing potential for innovative treatment strategies. Crucial for ongoing research to improve BC outcomes.

Golmohammadi M et al (2024).
Animal Model Exp Med.
PubMed:
39219410

Oroxylin A, a broad‑spectrum anticancer agent, relieves monocrotaline‑induced pulmonary arterial hypertension by inhibiting the Warburg effect in rats.

Oroxylin A (OA) inhibits glycolytic enzymes to treat liver cancer; it also decreases pulmonary arterial hypertension (PAH) in rats by reducing the Warburg effect of abnormal glucose metabolism. OA shows potential as a protective treatment for PAH.

Wang Y et al (2024).
Mol Med Rep.
PubMed:
39219283

Identification and validation of autophagy-related genes influenced by paris polyphylla in tongue cancer using network pharmacology.

This study examines how Paris polyphylla can be used to treat Tongue Squamous Cell Carcinoma by targeting specific molecular mechanisms, providing a potential new treatment option for this common form of oral cancer.

Zhou J et al (2024).
BMC Oral Health.
PubMed:
39215239

Triple negative breast cancer migration is modified by mitochondrial metabolism alteration induced by natural extracts of C. spinosa and P. alliacea.

Researchers studied natural extracts P2Et and Anamu-SC from plants for their anticancer properties on 4T1 breast cancer cells. Anamu-SC showed promising results by decreasing glucose consumption and ATP production, affecting mitochondrial function and cell migration. This study highlights the potential of natural products in modulating tumor metabolism.

Carlosama C et al (2024).
Sci Rep.
PubMed:
39215068

A comparative study of Mentha longifolia var. asiatica and Zygophyllum arabicum ZnO nanoparticles against breast cancer targeting Rab22A gene.

Researchers synthesized ZnO nanoparticles with extracts from Mentha longifolia var. asiatica and Zygophyllum arabicum to target Rab22A in breast cancer cells. Results showed significant cytotoxicity and apoptotic activity, with Z. arabicum being more effective. This research provides valuable insights for potential breast cancer treatments.

Bashir I and Dilshad E (2024).
PLoS One.
PubMed:
39213285

Extraction, Purification, Structural Characterization, and Antitumor Effects of Water-Soluble Intracellular Polysaccharide (IPSW-1) from Phellinus igniarius Mycelia.

Researchers isolated and studied a polysaccharide from a Chinese medicine fungus, finding it has antioxidant and antitumor properties by inhibiting cell proliferation and promoting apoptosis. This compound could be developed into a functional food.

Boateng ID, Guo YZ and Yang XM (2024).
J Agric Food Chem.
PubMed:
39205635

Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens.

Chaga mushroom extracts from birch species have moderate cytotoxic activity on various cancer cell lines. Extracts from certain species show stronger effects due to higher content of specific compounds. Chaga shows potential as a source of selective anticancer compounds.

Raal A et al (2024).
Pharmaceuticals (Basel).
PubMed:
39204121

Anticancer Effects of Secoiridoids-A Scoping Review of the Molecular Mechanisms behind the Chemopreventive Effects of the Olive Tree Components Oleocanthal, Oleacein, and Oleuropein.

This paper explores how key compounds in olive oil and leaf, like oleocanthal, oleacein, and oleuropein, can prevent cancer by inhibiting cell growth, inducing cell death, and disrupting cancer signaling pathways. Understanding these mechanisms can lead to new anti-cancer approaches.

Kusuma IY et al (2024).
Nutrients.
PubMed:
39203892