Cancer Studies

Chemical composition of essential and fixed oils of Tagetes erecta fruits (Iran) and their implications in inhibition of cancer signaling.

"Study on Tagetes erecta L. fruit oils from Iran: potent cytotoxic activity on glioblastoma cells, and significant inhibition of PI3K/AKT/mTOR signaling pathway. Potential as an anticancer agent. Important for cancer research."

Ahmadpour V et al (2024).
Sci Rep.
PubMed:
39181940

Sea buckthorn extract mitigates chronic obstructive pulmonary disease by suppression of ferroptosis via scavenging ROS and blocking p53/MAPK pathways.

SBE from sea buckthorn has protective effects on cardiovascular and respiratory diseases, including alleviating airway inflammation in mice. Further research is needed to understand its potential benefits for COPD.

Liu L et al (2024).
J Ethnopharmacol.
PubMed:
39181279

Reynoutria multiflora (Thunb.) Moldenke and its ingredient suppress lethal prostate cancer growth by inducing CDC25B-CDK1 mediated cell cycle arrest.

PM, a traditional Chinese medicine, shows potential as a treatment for prostate cancer by suppressing cancer growth in an AR-dependent manner. This study investigates its anti-tumor mechanism in advanced prostate cancer.

Zhou Q et al (2024).
Bioorg Chem.
PubMed:
39180863

Unveiling promising phytocompounds from Moringa oleifera as dual inhibitors of EGFR((T790M/C797S)) and VEGFR-2 in non-small cell lung cancer through in silico screening, ADMET, dynamics simulation, and DFT analysis.

Researchers identified five compounds from Moringa oleifera plant with strong potential as dual-acting drugs for treating NSCLC by targeting EGFR and VEGFR-2. Hesperetin, gossypetin, and quercetagetin show the most promise.

Masudur Rahman Munna M et al (2024).
J Genet Eng Biotechnol.
PubMed:
39179328

Lycorine (Lycoris radiata)-a unique natural medicine on breast cancer.

Lycorine from Amaryllidaceae plants shows potential in inhibiting breast cancer cell growth by inducing apoptosis and M phase cell cycle arrest. Further research needed for potential drug development.

Xue Q et al (2024).
J Cell Mol Med.
PubMed:
39175104

Alantolactone facilitates ferroptosis in non-small cell lung cancer through promoting FTH1 ubiquitination and degradation.

Alantolactone from Inula helenium kills lung cancer cells through ferroptosis by degrading FTH1 protein. Shows promise as a targeted anticancer treatment.

Huang Y et al (2024).
Chem Biol Drug Des.
PubMed:
39175059

Anticancer, antimicrobial and antioxidant activity of CuO-ZnO bimetallic nanoparticles: green synthesised from Eryngium foetidum leaf extract.

E. foetidum leaf extract was used to synthesize CuO-ZnO nanoparticles with potential anti-cancer, antimicrobial, and antioxidant properties. Results show promising cytotoxic effects on breast cancer cells and potent antimicrobial activity against various strains.

Daimari J and Deka AK (2024).
Sci Rep.
PubMed:
39174638

Cell fate simulation reveals cancer cell features in the tumor microenvironment.

Scientists used single-cell tracking and 3D modeling to study cancer cell behavior in pancreatic and cervical cancer. High levels of a specific modification were linked to enhanced growth in pancreatic cells. Understanding immune cell interactions and cell characteristics can help predict cancer cell fate in the tumor microenvironment.

Sato S, Rancourt A and Satoh MS (2024).
J Biol Chem.
PubMed:
39173950