Arctium lappa L. roots ameliorates cerebral ischemia through inhibiting neuronal apoptosis and suppressing AMPK/mTOR-mediated autophagy.

Arctium lappa L. roots have been shown to possess pharmacological benefits and protect neurons from injury in previous studies. This current study investigates whether the roots can prevent cerebral ischemia and the underlying mechanism. The results suggest that Arctium lappa L. root extract can reduce cerebral ischemic injury in rats and provides neuroprotection through multiple mechanisms. This study highlights the potential therapeutic value of Arctium lappa L. roots for treatment of cerebral ischemia.

Yang Y et al (2021).

Phytomedicine.

DOI:

10.1016/j.phymed.2021.153526

PubMed:

33691269

Structurally diverse alkaloids from Buxus sempervirens with cardioprotective activity.

Xiang ZN et al (2021).

Bioorg Chem.

DOI:

10.1016/j.bioorg.2021.104753

PubMed:

33652163

Cardioprotective Effect of Crude Extract and Solvent Fractions of Urtica simensis Leaves on Cyclophosphamide-Induced Myocardial Injury in Rats.

Tesfaye BA et al (2021).

J Exp Pharmacol.

DOI:

10.2147/JEP.S270038

PubMed:

33628065

Saponins in Chinese Herbal Medicine Exerts Protection in Myocardial Ischemia-Reperfusion Injury: Possible Mechanism and Target Analysis.

Wang R et al (2021).

Front Pharmacol.

DOI:

10.3389/fphar.2020.570867

PubMed:

33597866

Methanol (80%) leaf extract of Otostegia integrifolia Benth (Lamiaceae) lowers blood pressure in rats through interference with calcium conductance.

Degu A, Abebe A and Engidawork E (2021).

BMC Complement Med Ther.

DOI:

10.1186/s12906-021-03222-4

PubMed:

33541332

Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury.

Cheng Y et al (2021).

Theranostics.

DOI:

10.7150/thno.48436

PubMed:

33391509

Inhibition of Soybean 15-Lipoxygenase and Human 5-Lipoxygenase by Extracts of Leaves, Stem Bark, Phenols and Catechols Isolated From Lithraea caustica (Anacardiaceae).

Muñoz-Ramírez A et al (2020).

Front Pharmacol.

DOI:

10.3389/fphar.2020.594257

PubMed:

33390977

Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis.

Li Y et al (2021).

Redox Biol.

DOI:

10.1016/j.redox.2020.101771

PubMed:

33189984