Bauhinia championii Flavone Attenuates Hypoxia-Reoxygenation Induced Apoptosis in H9c2 Cardiomyocytes by Improving Mitochondrial Dysfunction.
- Liao P et al (2016).
- Molecules.
- PubMed:
- 27827932
Researchers evaluated the neuroprotective effect of SS in rats with cerebral ischemia. The rats were divided into control, ischemia/reperfusion (I/R), and two groups treated with different doses of SS extract for 15 days before I/R. The results showed that SS significantly decreased oxidative stress and DNA damage and increased brain ATP levels and the expression of anti-inflammatory cytokines in the brain tissues of cerebral ischemic rats compared to I/R rats. The study suggests that SS has antioxidant, anti-apoptotic, and anti-inflammatory activity, making it a potential therapeutic agent for preventing neuronal damage from cerebral ischemia.
Ruscogenin, a sapogenin from Ophiopogon japonicus, has been shown to protect against ischemic injury to the brain. Researchers investigated its effects on blood-brain barrier dysfunction after stroke and found that it decreased brain damage, improved neurological function, and increased blood flow in mice. In brain cells, ruscogenin increased cell viability, decreased leakage, and modulated tight junction expression. It also inhibited the expression of inflammatory markers and decreased reactive oxygen species generation. These findings suggest that ruscogenin has potential for preventing and treating stroke.