Molecular insights into the in silico discovery of corilagin from Terminalia chebula as a potential dual inhibitor of SARS-CoV-2 structural proteins.
- Pradeep S et al (2023).
- J Biomol Struct Dyn.
- PubMed:
- 36576118
Sweet violet syrup, used in traditional Persian medicine, may help treat COVID-19 symptoms by enhancing respiratory functions and reducing inflammation, according to a study. Confirmation from additional research is required. (40 characters)
Researchers in Malaysia investigated the potential of phytochemicals found in pea eggplant, a widely consumed vegetable, to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes COVID-19. The polyphenols from pea eggplant were docked with SARS-CoV receptors in molecular simulations and the best receptor-ligand complex was validated through molecular dynamics simulation. The study suggests that pea eggplant phytochemicals may have inhibitory properties against SARS-CoV-2.
Researchers developed a stable, water-soluble form of curcumin, called CDC, which effectively reduces lung injury and inflammation in mice following bacterial exposure. Recently, CDC was found to reduce gene and protein expression of key factors involved in COVID-19 pathogenesis. This review considers the potential of curcumin in treating COVID-19 and bacterial/viral-induced acute respiratory distress syndrome (ARDS) through modulating inflammation.
In this study, researchers investigated the potential benefits of using a traditional plant, Borage, in combination with syrup (BPS) in severe COVID-19 patients in an ICU setting. Borage is a good source of gamma-linolenic acid (GLA). The study aimed to find a possible curative treatment for COVID-19 patients, who still have a high mortality rate globally.
Researchers in Indonesia have identified four compounds from binahong leaves that could interact with the major protease of the SARS-CoV 2 virus. The compounds - procyanidin, oleic acid, methyl linoleic acid, and vitexin - were tested through molecular dynamics simulation, with procyanidin and vitexin having the best docking scores. While the two compounds showed good performance in interacting with the target protein, they did not conform as well as quercetin, a control ligand. The study may offer new avenues for COVID-19 treatments.