Network pharmacology prediction and experimental verification of Rhubarb-Peach Kernel promoting apoptosis in endometriosis.

Researchers investigated the anti-endometriosis effect of the traditional Chinese medicine pair "Rhubarb-Peach Kernel" (RP) and its mechanism of action. Using network pharmacology, molecular docking, and experimental verification, they found that RP induces apoptosis and could be effective in treating endometriosis.

Liao Z et al (2023).

BMC Complement Med Ther.

DOI:

10.1186/s12906-023-04084-8

PubMed:

37598188

GC-MS analysis and in silico docking of constituents of Cinnamomum malabatrum against CYP450 17α and CYP450 19 (Aromatase)- Key targets for hyperandrogenism.

Soumya V et al (2023).

Drug Res (Stuttg).

DOI:

10.1055/a-2142-5774

PubMed:

37591259

Isoalantolactone Suppresses Glycolysis and Resensitizes Cisplatin-Based Chemotherapy in Cisplatin-Resistant Ovarian Cancer Cells.

Isoalantolactone, a compound found in Herba Inulae, can inhibit glycolysis in cisplatin-resistant ovarian cancer cells and sensitize them to cisplatin-induced apoptosis. It also suppresses tumor growth in cisplatin-resistant tumors, offering a potential treatment for overcoming drug resistance in ovarian cancer.

Chun J et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms241512397

PubMed:

37569773

The Roles of Hormone Signals Involved in Rhizosphere Pressure Response Induce Corm Expansion in Sagittaria trifolia.

Compacted soil affects plant growth, leading to root growth stagnation and bending/thickening. Arrowhead corm expansion is affected by rhizosphere pressure and hormone levels, providing insights for studying similar developments in other plants.

Li E et al (2023).

Int J Mol Sci.

DOI:

10.3390/ijms241512345

PubMed:

37569720

Network pharmacology-based strategic prediction and target identification of apocarotenoids and carotenoids from standardized Kashmir saffron (Crocus sativus L.) extract against polycystic ovary syndrome.

Network pharmacology was used to identify therapeutic pathways of Crocus sativus extract for PCOS. Prominent targets and signaling pathways were found, suggesting the extract can regulate multiple pathways. Carotenoids and apocarotenoids in the extract are bioavailable and non-toxic.

Tiwari A et al (2023).

Medicine (Baltimore).

DOI:

10.1097/MD.0000000000034514

PubMed:

37565925

Relationship between seasonal variation in isoprene emission and plant hormone profiles in the tropical plant Ficus septica.

This study explored the relationship between plant hormones and isoprene emissions in Ficus septica. Long-term changes in isoprene emissions were influenced by temperature, light, and cytokinin levels. This research helps understand the regulation of isoprene production in plants.

Iqbal MA et al (2023).

Plant Biol (Stuttg).

DOI:

10.1111/plb.13565

PubMed:

37565537

Angelica sinensis polysaccharide ameliorates nonalcoholic fatty liver disease via restoring estrogen-related receptor α expression in liver.

Angelica sinensis polysaccharide (ASP) regulates liver fat accumulation by altering gut microbiota and increasing propionate and butyrate levels. It can be used to prevent nonalcoholic fatty liver disease (NAFLD).

Luo L et al (2023).

Phytother Res.

DOI:

10.1002/ptr.7982

PubMed:

37563852

Occurrence and conversion of progestogens and androgens are conserved in land plants.

Shiko G et al (2023).

New Phytol.

DOI:

10.1111/nph.19163

PubMed:

37559351