Integrating network pharmacology with molecular docking to rationalize the ethnomedicinal use of Alchornea laxiflora (Benth.) Pax & K. Hoffm. for efficient treatment of depression.
The study identified bioactive compounds in Alchornea laxiflora with potential antidepressant effects through molecular docking and network pharmacology. Key targets include SRC, EGFR, PIK3R1, AKT1, and MAPK1, suggesting a role in treating depression via PI3K-Akt and MAPK signaling pathways.
- Jain NK et al (2024).
- Front Pharmacol.
- PubMed:
- 38505421