Gastroenterology Studies

Polygonum sibiricum polysaccharides exert the antidepressant-like effects in chronic unpredictable mild stress-induced depressive mice by modulating microbiota-gut-brain axis.

Researchers studied the effects of Polygonum sibiricum polysaccharides (PSP), a component of a traditional Chinese medicine, on mice with depression caused by chronic mild stress. The study aimed to determine if PSP worked through the microbiota-gut-brain (MGB) axis. Mice treated with fecal microbiota transplantation from PSP-treated mice exhibited improved depressive behaviors and increased levels of neurotransmitters 5-hydroxytryptamine and norepinephrine while reducing pro-inflammatory cytokines and corticosterone. Administration of PSP and fecal microbiota transplantation also regulated signaling pathways, indicating that PSP exerts its antidepressant effects through the MGB axis.

Zhang Y et al (2023).
Phytother Res.
PubMed:
36996849

Earthworm-Driven Changes in Soil Chemico-Physical Properties, Soil Bacterial Microbiota, Tree/Tea Litter Decomposition, and Plant Growth in a Mesocosm Experiment with Two Plant Species.

Sofo A et al (2023).
Plants (Basel).
PubMed:
36986903