Diosgenin reduces bone loss through the regulation of gut microbiota in ovariectomized rats.
- Song C et al (2023).
- Gene.
- PubMed:
- 37001571
Researchers studied the effects of Polygonum sibiricum polysaccharides (PSP), a component of a traditional Chinese medicine, on mice with depression caused by chronic mild stress. The study aimed to determine if PSP worked through the microbiota-gut-brain (MGB) axis. Mice treated with fecal microbiota transplantation from PSP-treated mice exhibited improved depressive behaviors and increased levels of neurotransmitters 5-hydroxytryptamine and norepinephrine while reducing pro-inflammatory cytokines and corticosterone. Administration of PSP and fecal microbiota transplantation also regulated signaling pathways, indicating that PSP exerts its antidepressant effects through the MGB axis.