Gastroenterology Studies

Exploring the immunological mechanism of Houttuynia cordata in the treatment of colorectal cancer through combined network pharmacology and experimental validation.

Study identified active components of Houttuynia cordata for CRC treatment. Quercetin and kaempferol target genes IL1B, MMP9, CXCL8, and IL6, inhibiting cell growth and promoting apoptosis. Potential for immunomodulation in CRC treatment.

Li Y et al (2024).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
38888753

In Silico Analysis of Selective Bioactive Compounds from Acronychia Pedunculata as a Potential Inhibitor of HER2 in Colorectal Cancer.

Researchers studied compounds from Acronychia pedunculata for potential inhibition of HER2 in colorectal cancer. 12 compounds showed promising properties for drug-likeness and oral bioavailability, with two compounds showing strong binding affinities to HER2. Further experimental validation is needed.

Ramya S et al (2024).
J Pharm Bioallied Sci.
PubMed:
38882725

Modulation of gut microbiota by crude gac aril polysaccharides ameliorates diet-induced obesity and metabolic disorders.

Gac fruit polysaccharides (GAP) reduce obesity in mice by improving metabolic health, insulin sensitivity, gut microbiota, and liver steatosis. Potential for treating obesity-related disorders.

Lu TJ et al (2024).
Int J Biol Macromol.
PubMed:
38878919

Mechanism of 5-fluorouracil induced resistance and role of piperine and curcumin as chemo-sensitizers in colon cancer.

Researchers studied chemoresistance in colorectal cancer cells treated with 5-FU, finding various resistance mechanisms. Curcumin and piperine enhance 5-FU sensitivity, showing promise for improving chemotherapy effectiveness.

Bhattacharjya D and Sivalingam N (2024).
Naunyn Schmiedebergs Arch Pharmacol.
PubMed:
38878089

The anti-hyperplasia effect of polysaccharide from Prunella vulgaris L. on mammary gland hyperplasia in rats through regulation of the AKT-FOXO3a signaling pathway and intestinal flora.

Zhao H et al (2024).
J Sci Food Agric.
PubMed:
38872513