Gastroenterology Studies

23-Hydroxybetulinic acid attenuates 5-fluorouracil resistance of colorectal cancer by modulating M2 macrophage polarization via STAT6 signaling.

23-HBA from P. chinensis inhibits M2 macrophage polarization, decreasing resistance to 5-FU in colorectal cancer. Suppresses IL-10/STAT3/Bcl-2 pathway, enhancing 5-FU efficacy and reducing M2 macrophage presence in tumor tissues.

Fan Z et al (2024).
Cancer Immunol Immunother.
PubMed:
38554148