Genetics Studies

Combination of Radix Astragali and Safflower Promotes Angiogenesis in Rats with Ischemic Stroke via Silencing PTGS2.

Radix astragali-safflower (AS) has been used for centuries in China to treat patients with ischemic stroke (IS). In this study, network pharmacology was used to uncover the mechanism of AS in treating IS. AS was shown to promote angiogenesis, which was associated with PTGS2 silence. Middle cerebral artery occlusion/reperfusion (MCAO/R) model rats were then treated with AS and showed improved cerebral infarct volume, neurological and histopathological damage, inhibition of cell apoptosis, and increased levels of PDGF-BB, EPO, and TGF-β1. AS was found to promote angiogenesis in MCAO/R rats by reversing the down-regulation of VEGF and promoting the expression of CD31. The protective mechanism of AS for IS involves PTGS2 silence.

Xu S et al (2023).
Int J Mol Sci.
PubMed:
36768450