Genetics Studies

1,2,3,4,6-Pentagalloyl glucose of Pistacia lentiscus can inhibit the replication and transcription processes and viral pathogenesis of SARS-COV-2.

Researchers examined the effects of five active compounds from Pistacia sp. on key targets of the SARS-COV-2 virus. 1,2,3,4,6-pentagalloyl glucose (PG) was found to be the most effective, with strong binding affinities to helicase, RdRp, E protein, and 3CLpro, and was able to inhibit the replication and transcription processes, making it a potential antiviral treatment. The study suggests PG could also have anti-inflammatory and antioxidant properties.

Samandar F et al (2022).
Mol Cell Probes.
PubMed:
35843391