Genetics Studies

Natural plant products as potential inhibitors of RNA dependent RNA polymerase of Severe Acute Respiratory Syndrome Coronavirus-2.

Researchers investigated the interaction between phytochemicals from Indian medicinal plants and the RNA-dependent RNA polymerase (RdRP) of SARS-CoV-2. Using molecular docking and dynamics simulations, they identified four top phytochemicals, including cordifolide A and sitoindoside IX, which showed strong binding to RdRP and may serve as potential inhibitors. The study suggests that drug repurposing efforts can target RdRP inhibition and that natural compounds may hold promise as a treatment for COVID-19.

Koulgi S et al (2021).
PLoS One.
PubMed:
33984041