Accelerated delivery of dsRNA in lepidopteran midgut cells by a Galanthus nivalis lectin (GNA)-dsRNA-binding domain fusion protein.
- Martinez Z et al (2021).
- Pestic Biochem Physiol.
- PubMed:
- 33993971
Researchers investigated the interaction between phytochemicals from Indian medicinal plants and the RNA-dependent RNA polymerase (RdRP) of SARS-CoV-2. Using molecular docking and dynamics simulations, they identified four top phytochemicals, including cordifolide A and sitoindoside IX, which showed strong binding to RdRP and may serve as potential inhibitors. The study suggests that drug repurposing efforts can target RdRP inhibition and that natural compounds may hold promise as a treatment for COVID-19.