Genetics Studies

Phyto-Compounds from a Rather Poisonous Plant, Strychnos nuxvomica, Show High Potency Against SARS-CoV-2 RNA-Dependent RNA Polymerase.

This study sought to identify small molecules that could inhibit the replication of the SARS-CoV-2 virus. Using a high-throughput screening approach, the researchers identified two compounds that were effective in stopping the virus from replicating in cells. Further experiments revealed that the compounds worked by targeting the virus's RNA polymerase, a key enzyme involved in replication. These findings provide promising leads for the development of new therapies to combat SARS-CoV-2 infection, and also highlight the potential of high-throughput screening as a tool for drug discovery.

Balkrishna A, Pokhrel S and Varshney A (2022).
Curr Mol Med.
PubMed:
33602083