Analgesic and antipyretic activities of Drymaria cordata (Linn.) Willd (Caryophyllaceae) extract.
- Akindele AJ, Ibe IF and Adeyemi OO (2011).
- Afr J Tradit Complement Altern Med.
- PubMed:
- 23983316
Researchers examined the pain-relieving effects of Agrimonia pilosa Ledeb extract in mice. They found that oral administration of the extract (200 mg/kg) reduced pain as measured by various tests. The extract also reduced the nociceptive response to a substance that causes pain when injected into the spinal cord. The antinociceptive effect was blocked by a drug that blocks alpha-2 adrenergic receptors, but not by drugs that block opioid or serotonergic receptors. These findings suggest that Agrimonia pilosa Ledeb extract has pain-relieving properties, and that it may work by affecting alpha-2 adrenergic receptors.