Acute and chronic toxicity in Sprague-Dawley rats of orally-administered total lignans from Arctii Fructus, a potential therapeutic drug for diabetes.
TLAF, a compound from Arctii Fructus, showed low toxicity in rats at 1,800 mg/kg for 26 weeks. It has potential for clinical treatment of diabetes.
- Mei J et al (2024).
- Regul Toxicol Pharmacol.
- PubMed:
- 38070762