Phytochemistry Studies

Integrated physicochemical, hormonal, and transcriptomic analysis reveals the underlying mechanism of callus formation in Pinellia ternata hydroponic cuttings.

Researchers developed a highly efficient cultivation technology for hydroponic cuttings of a medicinal herb. It increases seedling production rate and addresses issues in traditional cultivation methods. However, the callus formation mechanism in hydroponic cuttings is still unclear.

Duan X et al (2023).
Front Plant Sci.
PubMed:
37409296

Liquid chromatography-tandem mass spectrometry analysis of a ratio-optimized drug pair of Sophora flavescens Aiton and Coptis chinensis Franch and study on the mechanism of anti-colorectal cancer effect of two alkaloids thereof.

The drug combination of Aiton (Kushen) and Franch. (Huanglian) is used to treat laxation. This study focused on their potential anti-cancer effects against colorectal cancer. The research found that a 1:1 ratio of Kushen and Huanglian had the best anti-cancer effect. The active components, matrine and berberine, were evaluated and found to reduce the growth of colorectal cancer in mice. Additionally, the combination of matrine and berberine showed better efficacy than using them alone. The study also identified and quantified the chemical constituents of the drug pair. The findings suggest that the combination of matrine and berberine could inhibit colorectal cancer by improving intestinal microbiota and regulating a signaling pathway.

Chen Z et al (2023).
Front Oncol.
PubMed:
37404762

Assessment of anticancer, antimicrobial, antidiabetic, anti-obesity and antioxidant activity of Ocimum Basilicum seeds essential oil from Palestine.

This study explored the therapeutic properties of basil seed essential oil, including its antioxidant, anti-obesity, antidiabetic, antibacterial, and cytotoxic activities. It adds to the search for natural compounds for obesity, diabetes, infections, cancer, and oxidative stress.

Eid AM et al (2023).
BMC Complement Med Ther.
PubMed:
37403162