Bioactive content and phenolic compounds of common medlar (Mespilus germanica L.) and Stern's medlar (M. canescens Phipps).
- Sadeghinejad Z, Erfani-Moghadam J and Khadivi A (2022).
- Food Sci Nutr.
- DOI:
- 10.1002/fsn3.2814
- PubMed:
- 35702277
The study aimed to optimize a method for determining cholinesterase activity using high-performance liquid chromatography and then investigate the potential of isoquinoline alkaloids and plant extracts for inhibiting acetylcholinesterase and butyrylcholinesterase activity. The HPLC method successfully eliminated interference from certain alkaloids and allowed for identification of bioactive compounds in the plant extracts. Results showed high inhibition activity, particularly in sanguinarine and chelerythrine alkaloids and the May aerial plant extract. These extracts may be recommended for further in vivo testing to confirm cholinesterase inhibition activity.
Chrysin, a natural molecule found in plants, has various health benefits such as antioxidant, anti-inflammatory, anti-cancer, neuroprotective, and anti-apoptotic effects. Researchers have found that chrysin also exhibits anxiolytic and antidepressant-like effects through its interaction with neurotransmitter systems, particularly the GABAergic and serotonergic, and activation of neurotrophic factors. The antioxidant and anti-inflammatory activities of chrysin may also contribute to its therapeutic use for anxiety and depression disorders. These pre-clinical findings suggest that chrysin could be a promising novel therapy for these disorders.