Phytochemicals of Euphorbia hirta L. and Their Inhibitory Potential Against SARS-CoV-2 Main Protease.
Scientists investigated the potential of a medicinal plant, used in Asia to treat respiratory disorders, to inhibit the SARS-CoV-2 main protease, a drug target for COVID-19. They used phytochemical mining and virtual screening to assess the potential of 298 phytochemicals for therapeutic use against COVID-19. They found 170 phytochemicals to have comparable or better binding properties for the SARS-CoV-2 Mpro target than known inhibitors. The study reaffirms the potential of the plant and its phytochemicals for COVID-19 treatment and highlights the utility of phytochemical mining and virtual screening in drug discovery.
- Cayona R and Creencia E (2022).
- Front Mol Biosci.
- PubMed:
- 35187071