Phytochemistry Studies

Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease.

Researchers identified a previously unknown indole alkaloid and 22 known compounds in Vinca minor L. plants using a range of analytical techniques. They screened these alkaloids for their ability to inhibit enzymes involved in cognitive function and found that (-)-2-ethyl-3[2-(3-ethylpiperidinyl)-ethyl]-1H-indole has significant butyrylcholinesterase inhibition activity, with potential to cross the blood-brain barrier. This finding could help develop new treatments for neurodegenerative diseases.

Vrabec R et al (2022).
Phytochemistry.
PubMed:
34798410