Phytochemistry Studies

Neuroprotective effect of Bryophyllum pinnatum flavonoids against aluminum chloride-induced neurotoxicity in rats.

This study looked at the potential for a flavonoid-rich extract of Betula pendula leaves to protect against neurotoxicity caused by aluminum in rats. The extract was given orally for 21 days and was found to reduce oxidative damage, down-regulate acetylcholinesterase mRNA, and improve histological features in the brain. Molecular interactions were also investigated and strong connections were found with key antioxidant enzymes. These findings suggest a neuroprotective effect of the extract against aluminum-induced neurotoxicity.

Ogidigo JO et al (2022).
Toxicol Mech Methods.
PubMed:
34663170