Phytochemistry Studies

Flavonoids in Ampelopsis grossedentata as covalent inhibitors of SARS-CoV-2 3CL(pro): Inhibition potentials, covalent binding sites and inhibitory mechanisms.

Researchers identified the key constituents in Ampelopsis grossedentata extract (AGE) responsible for inhibiting coronavirus 3C-like protease (3CL), a target for treating COVID-19. Flavonoid-rich fractions from AGE were found to strongly inhibit SARS-CoV-2-3CL, with dihydromyricetin, isodihydromyricetin, and myricetin identified as the most effective compounds. The researchers found that myricetin covalently binds to SARS-CoV-2-3CL at Cys300 and Cys44, while dihydromyricetin and isodihydromyricetin covalently bind at Cys300, suggesting that these compounds could be used to develop new antiviral agents.

Xiong Y et al (2021).
Int J Biol Macromol.
PubMed:
34333006

Characterization of essential oils and volatiles from the aerial parts of Mentha pulegium L. (Lamiaceae) using microwave-assisted hydrodistillation (MAHD) and headspace solid phase microextraction (HS-SPME) in combination with GC-MS.

Mohammadhosseini M, Venditti A and Mahdavi B (2023).
Nat Prod Res.
PubMed:
34328036

Phytochemical Composition, Antioxidant, Antiacetylcholinesterase, and Cytotoxic Activities of Rumex crispus L.

Researchers evaluated three solvents of increasing polarity to extract phenolic compounds from the aerial part of L. plant. The methanol extract had significant anti-oxidant and anti-cholinesterase activities, while the dichloromethane extract had the highest cytotoxic activity against cancer cells. GC-MS analysis identified three new compounds, and HPLC chromatograms showed several phenolic compounds. The study suggests that L. plant extracts could be considered as natural supplements for food and pharmaceuticals due to their phenolic compounds.

Saoudi MM et al (2021).
Int J Anal Chem.
PubMed:
34306086