Physicochemical, biological properties, and flavour profile of Rosa roxburghii Tratt, Pyracantha fortuneana, and Rosa laevigata Michx fruits: A comprehensive review.
- Li H et al (2022).
- Food Chem.
- PubMed:
- 34339923
Researchers identified the key constituents in Ampelopsis grossedentata extract (AGE) responsible for inhibiting coronavirus 3C-like protease (3CL), a target for treating COVID-19. Flavonoid-rich fractions from AGE were found to strongly inhibit SARS-CoV-2-3CL, with dihydromyricetin, isodihydromyricetin, and myricetin identified as the most effective compounds. The researchers found that myricetin covalently binds to SARS-CoV-2-3CL at Cys300 and Cys44, while dihydromyricetin and isodihydromyricetin covalently bind at Cys300, suggesting that these compounds could be used to develop new antiviral agents.
Researchers evaluated three solvents of increasing polarity to extract phenolic compounds from the aerial part of L. plant. The methanol extract had significant anti-oxidant and anti-cholinesterase activities, while the dichloromethane extract had the highest cytotoxic activity against cancer cells. GC-MS analysis identified three new compounds, and HPLC chromatograms showed several phenolic compounds. The study suggests that L. plant extracts could be considered as natural supplements for food and pharmaceuticals due to their phenolic compounds.