Phytochemistry Studies

The Main Alkaloids in Uncaria rhynchophylla and Their Anti-Alzheimer's Disease Mechanism Determined by a Network Pharmacology Approach.

This study used a network pharmacology approach to investigate the potential of certain alkaloids found in Uncaria Rhynchophylla (UR) for treating Alzheimer's disease (AD). The researchers identified 10 alkaloids that corresponded to 90 anti-AD targets. They found that corynoxine, corynantheine, isorhynchophylline, dihydrocorynatheine, and isocorynoxeine are likely to become key components for AD treatment. KEGG pathway enrichment analysis revealed that the Alzheimer's disease pathway was the most significantly enriched in alkaloids against AD. The study also found that UR alkaloids directly exert an AD treatment effect by acting on multiple pathological processes in AD. These findings suggest that UR alkaloids could be further studied as potential treatments for AD.

Zeng P et al (2021).
Int J Mol Sci.
PubMed:
33807157