Phytochemistry Studies

Sedative and hypnotic effects of Perilla frutescens essential oil through GABAergic system pathway.

A study investigated the sedative and hypnotic effects of Perilla frutescens essential oil (PFEO) through inhalation administration for insomnia treatment, as traditional Chinese medicine suggests depression syndrome is a core pathogenesis of insomnia. Results showed that PFEO exhibited sedative and hypnotic effects, increased total sleep time, and decreased wake time, which suggest it may have therapeutic potential for insomnia treatment. These findings provide insight into the pharmacology and mechanism of PFEO and support the use of traditional Chinese medicine for treating insomnia.

Zhong Y et al (2021).
J Ethnopharmacol.
PubMed:
33246117