Phytochemistry Studies

Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain.

Researchers isolated six compounds from the roots of a plant called Heliopsis helianthoides var. scabra and tested their effects on brain tumor metastasis formation. Two of the compounds, helioxanthin (3) and (7E)-7,8-dehydroheliobuphthalmin (4), inhibited the migration of melanoma and brain endothelial cells. Compound 3 also reduced the adhesion of melanoma cells to the brain endothelium and enhanced the barrier function of the blood-brain barrier. These findings suggest that compounds 3 and 4 have the potential to interfere with different steps of brain metastasis formation and to enhance the barrier function of cerebral endothelial cells.

Hajdu Z et al (2014).
J Nat Prod.
PubMed:
25479041