Saponins from Rubus parvifolius L. induce apoptosis in human chronic myeloid leukemia cells through AMPK activation and STAT3 inhibition.
- Ge YQ et al (2014).
- Asian Pac J Cancer Prev.
- PubMed:
- 25041018
Researchers have isolated four new alkaloids and ten known analogues from the whole plant of Lycopodiastrum casuarinoides. The new compounds' structures were determined using a variety of spectroscopic and chemical methods. Notably, compound 4 was a lycopodium alkaloidal glycoside never before reported. Four of the isolated compounds showed significant inhibitory activity against acetylcholinesterase, which is linked to Alzheimer's disease. The structure-activity relationships were discussed, potentially informing future treatments.