Acetylcholinesterase inhibitory activity and chemical composition of commercial essential oils.

Researchers screened commercially available essential oils and their components for their acetylcholinesterase (AChE) inhibitory activity through a microplate assay method. Gas chromatography-mass spectrometry (GC-MS) analysis was carried out to characterize oil profiles and the relationships between the oil components and AChE inhibitory activity. All oils, except Artemisia dracunculus L. from Hungary, exhibited AChE inhibitory activity. Eugenol was found to be a potent AChE inhibitor, and this is the first study to report its IC(50) value. However, the ratio of active components contributing to the AChE inhibitory activity of the oils was low, raising concerns about their potential risks. This study is the first to reveal the AChE inhibitory activity of Inula graveolens L. oil.

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