Ceratonia siliqua pods (Carob) methanol extract alleviates doxorubicin-induced nephrotoxicity via antioxidant, anti-inflammatory and anti-apoptotic pathways in rats.
- Atta AH et al (2023).
- Environ Sci Pollut Res Int.
- PubMed:
- 37341944
This is a correction for a study on the impact of adding Lam. leaf to Fuzhuan Brick Tea. It discusses sensory properties, volatile profiles, and anti-obesity activity.
In this study, researchers investigated the cellular mechanism behind the anti-inflammatory effects of ellagic acid, a compound found in peels of L. that has traditional uses in treating traumatic hemorrhage. They found that ellagic acid inhibited the phosphorylation of ERK and subsequent neuroinflammation induced by lipopolysaccharides (LPSs) in treated BV-2 cells. Additionally, ellagic acid attenuated LPS-induced changes in various biomarkers associated with neuroinflammation, protein aggregation, and programmed cell deaths in the infused substantia nigra. The results suggest that ellagic acid has potential as a neuroprotective agent through inhibiting MEK1-ERK signaling and promoting M2 microglial polarization.
Shugan Jieyu Capsule (SJC) is a Chinese medicine compound that uses Hypericum perforatum and Acanthopanacis Senticosi. It is currently used to treat depression, but how it works is not fully understood. Further research is needed to determine the mechanism of action. Understanding this could lead to improved treatment options and potentially help more people in the future.