Identification of Chemical Constituents in Blumea balsamifera Using UPLC-Q-Orbitrap HRMS and Evaluation of Their Antioxidant Activities.
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- Molecules.
- PubMed:
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Insulin resistance (IR) leads to diabetes and cardiovascular issues. Natural substances like berberine, quercetin, and silymarin combat this by targeting insulin signaling and reducing inflammation. Further research on human usage is needed.
This study examined the effects of saponified lipophilic berry extract (LSBE) on breast cancer cell lines. LSBE was found to inhibit the proliferation of breast cancer cells in a concentration-dependent manner, with a mean IC50 of 16 µM. It also demonstrated strong antioxidant activity, reducing ROS levels in both cell lines. Additionally, LSBE induced significant alterations in late-stage apoptotic cells. These findings suggest that the carotenoids in LSBE may have potential as nutraceuticals in breast cancer therapy. Further research should be conducted to explore this possibility.