Paeonol, the active component of Cynanchum paniculatum, ameliorated schizophrenia-like behaviors by regulating the PI3K-Akt-GSK3β-NF-κB signalling pathway in MK-801-treated mice.

Cynanchum paniculatum has been traditionally utilized in East Asia as an analgesic or antiviral. Some traditional medicinal books also mention its use in treating psychotic symptoms. The study explores its potential benefits for treating schizophrenia-like symptoms in rats. The extracts showed a promising reduction in behavioral abnormalities, leading to the possibility of this plant being a useful resource in the development of antipsychotic medicines.

Bae HJ et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116627

PubMed:

37164258

Paris polyphylla extract attenuates colitis in mice by regulating PPAR-γ mediated Treg/Th17 balance.

He L et al (2023).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2023.116621

PubMed:

37164256

BuOH fraction of Salix Babylonica L. extract increases pancreatic beta-cell tumor death at lower doses without harming their function.

Salix babylonica L. leaf extract has different effects on pancreatic tumor cells. EtOAc fraction causes cell death, while BuOH fraction kills cells with less damage.

Kacar AK et al (2023).

Toxicol In Vitro.

DOI:

10.1016/j.tiv.2023.105609

PubMed:

37164183

In vivo anti-hepatitis B activity of Artemisia argyi essential oil-loaded nanostructured lipid carriers. Study of its mechanism of action by network pharmacology and molecular docking.

Zhang Z et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.154848

PubMed:

37163901

Aged black garlic (Allium sativum L.) and aged black elephant garlic (Allium ampeloprasum L.) alleviate obesity and attenuate obesity-induced muscle atrophy in diet-induced obese C57BL/6 mice.

Garlic helps with obesity and muscle atrophy. Aged black garlic and aged black elephant garlic enhance muscle growth through Akt/mTOR/p70 signaling.

Chae J et al (2023).

Biomed Pharmacother.

DOI:

10.1016/j.biopha.2023.114810

PubMed:

37163777

Ohwia caudata extract relieves the IL-17A-induced inflammatory response of synoviocytes through modulation of SOCS3 and JAK2/STAT3 activation.

Lu CY et al (2023).

Environ Toxicol.

DOI:

10.1002/tox.23818

PubMed:

37163279

Full-length transcriptome analysis of Zanthoxylum nitidum (Roxb.) DC.

Zhu Y et al (2023).

PeerJ.

DOI:

10.7717/peerj.15321

PubMed:

37163151

De novo transcriptome analysis and identification of defensive genes in garlic (Allium sativum L.) using high-throughput sequencing.

Prajapati MR et al (2023).

J Genet Eng Biotechnol.

DOI:

10.1186/s43141-023-00499-5

PubMed:

37162611