Integrative Analysis of the Transcriptome and Metabolome Reveals the Developmental Mechanisms and Metabolite Biosynthesis of the Tuberous Roots of Tetrastigma hemsleyanum.
- Hang S et al (2023).
- Molecules.
- PubMed:
- 36985574
This study explored the effects of two bioactive components of a traditional Chinese herbal medicine, GEB, on cognitive dysfunction in vascular dementia. The effectiveness of Gastrodin and Gastrodigenin was tested using various methods, including a water maze test and immunohistochemistry. The study showed that these components attenuated learning memory dysfunction and neuronal damage, reduced protein accumulation in the brain tissue and improved energy metabolism disorders in rats. This suggests that these components may provide neuroprotective effects by regulating energy metabolism and mitochondrial function in vascular dementia.
Researchers examined the phytochemical composition and biological activities of extracts from . Four solvents of varying polarity were used for extraction, and the extracts were tested for their chemical composition, antioxidant, anti-Alzheimer, and antibacterial properties. The MeOH extract had strong antioxidant and antibacterial activity, while the EtOAc extract had strong anti-Alzheimer and anti-cancer activity. Ten previously unidentified chemical compounds were also discovered. This study highlights the potential of for therapeutic applications.