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Withania somnifera influences MDMA-induced hyperthermic, cognitive, neurotoxic and neuroinflammatory effects in mice.

This study investigated the effects of Withania somnifera (WS) in preventing the neurotoxicity and memory impairments caused by MDMA. Mice were pretreated with vehicle or WSE before being randomly assigned into four groups: saline, WSE, MDMA alone, or WSE plus MDMA. Mice that were treated with only MDMA showed a decrease in dopamine levels and an increase in gliosis and hyperthermia, leading to memory impairments, while mice treated with both WSE and MDMA showed protection against the noxious effects of MDMA. This study suggests that WSE may be beneficial in counteracting the harmful effects of MDMA on the brain.

Costa G et al (2023).
Biomed Pharmacother.
PubMed:
36905810