Genome-Wide Association Analysis of Fruit Shape-Related Traits in Areca catechu.
- Ding H et al (2023).
- Int J Mol Sci.
- DOI:
- 10.3390/ijms24054686
- PubMed:
- 36902116
Type 2 diabetes (T2DM) and Alzheimer's disease (AD) share similar characteristics and common therapy options, including bioactive compounds found in fruits and vegetables. Bitter melon, a plant utilized for its glucose-lowering effects, has received recognition for its beneficial effects in treating T2DM and related metabolic conditions. Pre-clinical studies have identified multiple mechanisms by which bitter melon's bioactive components may be effective in reducing hyperglycemia and blocking the formation of amyloid plaques in AD. Further studies are necessary to establish its clinical efficacy in treating metabolic and neurodegenerative disorders.
The leaves of olive trees contain bioactive compounds, including oleuropein and hydroxytyrosol, which have medicinal properties to fight Alzheimer's disease (AD). These compounds reduce the formation of amyloid-β and neurofibrillary tangles, and OL demonstrated high inhibitory activity in cholinergic tests. They also decrease neuroinflammation and oxidative stress, which may contribute to their protective effects. Limited research indicates that consuming OL promotes autophagy and restores loss of proteostasis in AD models. Olive phytochemicals show promise as an adjuvant in AD treatment.