Proposal of novel ApoE4 inhibitors from the natural spice Cinnamon for the treatment of Alzheimer's disease: Ab initio molecular simulations.

Researchers used molecular techniques to investigate the interactions between apolipoprotein E4 (ApoE4) and cinnamon-derived compounds for developing effective diagnostic strategies and treatment for Alzheimer's disease (AD). Epicatechin was found to have the highest binding affinity to ApoE4 by forming strong hydrogen bonds with specific residues. Adding a hydroxyl group to epicatechin increased its binding affinity to ApoE4, indicating promising therapeutic candidates for AD.

Shaji D et al (2023).

Biophys Chem.

DOI:

10.1016/j.bpc.2023.106990

PubMed:

36898350

Stigmasterol isolated from Azadirachta indica flowers attenuated glutamate-induced neurotoxicity via downregulation of the Cdk5/p35/p25 signaling pathway in the HT-22 cells.

The brain of neurodegenerative disease (ND) patients had increased levels of glutamate, causing damage to mitochondria and leading to neurotoxicity. A study investigated the neuroprotective effects of stigmasterol, a natural compound, against glutamate-induced neurotoxicity and found that stigmasterol restored mitochondrial function and reduced neurotoxicity. These findings suggest that stigmasterol may be a potential treatment for ND.

Mongkolpobsin K et al (2023).

Phytomedicine.

DOI:

10.1016/j.phymed.2023.154728

PubMed:

36898255

Exploring of the ameliorative effects of Nerium (Nerium oleander L.) ethanolic flower extract in streptozotocin induced diabetic rats via biochemical, histological and molecular aspects.

Battal A et al (2023).

Mol Biol Rep.

DOI:

10.1007/s11033-023-08332-5

PubMed:

36897524

Upregulation of tandem duplicated BoFLC1 genes is associated with the non-flowering trait in Brassica oleracea var. capitata.

Kinoshita Y, Motoki K and Hosokawa M (2023).

Theor Appl Genet.

DOI:

10.1007/s00122-023-04311-3

PubMed:

36897379

A New Monoterpene Alkaloid from Incarvillea sinensis with Migration Inhibitory Activity on Cancer Cell.

Song W et al (2023).

Chem Biodivers.

DOI:

10.1002/cbdv.202201203

PubMed:

36896496

Genome-wide identification and expression analysis of MADS-box transcription factors reveal their involvement in sex determination of hardy rubber tree (Eucommia ulmoides oliv.).

Zhang X et al (2023).

Front Genet.

DOI:

10.3389/fgene.2023.1138703

PubMed:

36896236

Genome-wide analysis of R2R3-MYB transcription factors in Boehmeria nivea (L.) gaudich revealed potential cadmium tolerance and anthocyanin biosynthesis genes.

Feng X et al (2023).

Front Genet.

DOI:

10.3389/fgene.2023.1080909

PubMed:

36896232

Brucea javanica oil alleviates intestinal mucosal injury induced by chemotherapeutic agent 5-fluorouracil in mice.

Zheng X et al (2023).

Front Pharmacol.

DOI:

10.3389/fphar.2023.1136076

PubMed:

36895947