In Vitro Evaluation of Antiprotozoal Properties, Cytotoxicity Effect and Anticancer Activity of New Essential-Oil Based Phytoncide Mixtures.
- Iwiński H et al (2023).
- Molecules.
- PubMed:
- 36771061
The aerial parts of a plant species contain bioflavonoids, including cupressuflavone (CPF), a biflavonoid with various biological activities. To improve the bioavailability of CPF, three self-emulsifying drug delivery systems (SEDDS) were prepared and administered via the intranasal route to rats. Formulations B and C decreased the locomotor activity and balance of rats, with formula C at an intranasal dose of 5 mg/kg having the strongest effect. This study suggests that nose-to-brain drug delivery may be an effective method for treating neurological disorders.