Integrative metabolome and transcriptome analyses reveal the molecular mechanism underlying variation in floral scent during flower development of Chrysanthemum indicum var. aromaticum.
- Zhu L et al (2022).
- Front Plant Sci.
- PubMed:
- 36733600
Gelsemine, an alkaloid found in plants with therapeutic and toxic effects, may be involved in the modulation of GABA receptors (GABARs) responsible for the properties of benzodiazepines (BDZs), drugs used to treat anxiety, insomnia, and pain. Through electrophysiological recordings in HEK293 cells and cortical neurons, researchers discovered that gelsemine acts as a negative modulator of GABARs and GABAergic synaptic function, leading to toxicity. However, its presynaptic effects also provide a potential mechanism for its therapeutic effects. These findings improve understanding of gelsemine's effects in the nervous system and suggest potential new targets for therapeutic agents.
Rosemary essential oil was tested for its pain-relieving properties in mice. The study found that the antinociceptive effect of the oil may be mediated through the NO/cGMP/K ATP pathway.