All Studies

Corrigendum to "Laurus nobilis ethanolic extract attenuates hyperglycemia and hyperinsulinemia-induced insulin resistance in HepG2 cell line through the reduction of oxidative stress and improvement of mitochondrial biogenesis - Possible implication in pharmacotherapy" [Mitochondrion 59 (2021) 190-213].

Bourebaba N et al (2023).
Mitochondrion.
PubMed:
36725392

Protective effects of berberine against β-amyloid-induced neurotoxicity in HT22 cells via the Nrf2/HO-1 pathway.

This study explored the potential neuroprotective effects of berberine (BBR) against Alzheimer's disease (AD) in vitro. Researchers established an apoptotic model in HT22 cells induced by Aβ and treated them with BBR. Results showed that BBR improved cell viability, inhibited Aβ-induced apoptosis and intracellular ROS levels, and intensified the activity of Nrf2/HO-1 antioxidants in HT22 cells. It also restrained the mitochondrial pathway of cellular apoptosis by decreasing the rate of p-p65/p65, cytochrome C, and cleaved caspase-3. This led the researchers to conclude that BBR provides neuroprotectiveness by alleviating oxidative stress and inhibiting the mitochondrial pathway of cellular apoptosis.

Zhang RL et al (2023).
Bioorg Chem.
PubMed:
36724611

Two independent loss-of-function mutations in anthocyanidin synthase homeologous genes are responsible for the all-green phenotype of sweet basil.

Gonda I et al (2023).
Physiol Plant.
PubMed:
36724166