All Studies

Phytotherapy of mood disorders in the light of microbiota-gut-brain axis.

Research has revealed potential herbal medicines for treating mild mood disorders, but with unclear active components. The microbiota-gut-brain axis offers new avenues for treatment and prevention of mood disorders.

Korczak M et al (2023).
Phytomedicine.
PubMed:
36641978

Curcumin attenuates morphine dependence by modulating μ-opioid receptors and glial cell-activated neuroinflammation in rat.

Curcumin, a natural compound found in turmeric, was investigated for its potential to reduce opioid dependence in rats. The study used immunofluorescence staining and ELISA methods to evaluate cytokine levels, and western blotting to evaluate the expression of μ-opioid receptors. Results showed that curcumin administration significantly attenuated the symptoms of morphine withdrawal syndrome and reduced cytokine levels and inflammation in the prefrontal cortex. Additionally, the expression of μ-opioid receptors was reduced by curcumin. This study highlights the potential of curcumin as a treatment for opioid dependence by targeting neuroinflammation.

Sheikholeslami MA et al (2023).
Neuropeptides.
PubMed:
36640553