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Biochemical and behavioral effects of rosmarinic acid treatment in an animal model of Parkinson's disease induced by MPTP.

Researchers evaluated the potential neuroprotective effects of rosmarinic acid (RA) in a murine model of Parkinson's disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). RA was found to prevent hyperlocomotion behavior in MPTP-treated animals and improve the monoaminergic system in healthy animals. RA also increased dopaminergic signaling in the parkinsonian mice, indicating potential neuroprotective properties for RA in preventing behavioral features observed in PD and improving neurotransmission in the healthy brain.

Presti-Silva SM et al (2023).
Behav Brain Res.
PubMed:
36526017