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Plant lectins as versatile tools to fight coronavirus outbreaks.

Plant lectins could be used to combat COVID-19 pandemics by masking the non-glycosylated receptor binding domain of the virus and the corresponding region of the receptor. The ability of plant lectins to interact with the N- and O-glycans present on the spike proteins and their receptors have been analyzed, as well as the in vitro and in vivo anti-COVID-19 activity reported for them. Possible ways for delivery of lectins to block the spikes and/or their receptors are also discussed.

Simplicien M et al (2023).
Glycoconj J.
PubMed:
36418811