The Neuroprotective Role of Acorus calamus in Developmental and Histopathological Changes in Autism-Induced Wistar Rats.
Researchers created a rat model of autism by administering a drug called sodium valproate to pregnant rats on the 12th day of pregnancy. They then gave an ethanolic extract of Withania somnifera, a medicinal plant, to some of the rat pups in the autism-induced group. After 15 days of the drug exposure, the rats were sacrificed, and their brain tissue was collected for histopathological analysis. Results showed that autism-induced rat pups showed delayed appearance of neurological reflexes and neurodegenerative changes were observed in group II. However, group III (autism treated with the plant extract) did not show significant alteration, suggesting that the plant extract protected against autism pathology.
- Ukkirapandian K et al (2022).
- Cureus.
- DOI:
- 10.7759/cureus.29717
- PubMed:
- 36340563