All Studies

The Neuroprotective Role of Acorus calamus in Developmental and Histopathological Changes in Autism-Induced Wistar Rats.

Researchers created a rat model of autism by administering a drug called sodium valproate to pregnant rats on the 12th day of pregnancy. They then gave an ethanolic extract of Withania somnifera, a medicinal plant, to some of the rat pups in the autism-induced group. After 15 days of the drug exposure, the rats were sacrificed, and their brain tissue was collected for histopathological analysis. Results showed that autism-induced rat pups showed delayed appearance of neurological reflexes and neurodegenerative changes were observed in group II. However, group III (autism treated with the plant extract) did not show significant alteration, suggesting that the plant extract protected against autism pathology.

Ukkirapandian K et al (2022).
Cureus.
PubMed:
36340563

Neuroprotective Effects of Natural Antioxidants Against Branched-Chain Fatty Acid-Induced Oxidative Stress in Cerebral Cortex and Cerebellum Regions of the Rat Brain.

Valproic acid (VPA) is a neurotoxic fatty acid that may cause oxidative stress. In a study using rat brains, researchers tested the protective effects of antioxidants (melatonin, quercetin, and piperine) on VPA-induced stress. Results showed that these antioxidants were effective in preventing VPA-induced oxidative stress and mitigated the effects of VPA on certain brain activities. This suggests that a diet high in these antioxidants could be beneficial in combatting the negative effects of VPA.

Chaudhary S, Pinky and Parvez S (2022).
ACS Omega.
PubMed:
36340064

Comparative transcriptome and metabolome analysis reveal key regulatory defense networks and genes involved in enhanced salt tolerance of Actinidia (kiwifruit).

Abid M et al (2022).
Hortic Res.
PubMed:
36338850