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The Isolation and Preparation of Samwinol from Dracocephalum heterophyllum and Prevention on Aβ(25-35)-Induced Neuroinflammation in PC-12 Cells.

Scientists obtained samwinol from traditional Chinese Tibetan medicine by chromatography separation and investigated its effects on protecting cells against neurotoxicity caused by amyloid beta protein fragment. The results showed that samwinol increased cell viability, inhibited the production of reactive oxygen species, and suppressed ERK/AKT phosphorylation while promoting Nrf2/HO-1 signaling. Samwinol has significant anti-neuroinflammatory and antioxidant activities, suggesting its potential use for treating Alzheimer's disease. Further studies are needed to confirm its efficacy.

Li C et al (2022).
Int J Mol Sci.
PubMed:
36232874