Large-scale analysis of protein crotonylation reveals its diverse functions in Pinellia ternata.
- Guo W et al (2022).
- BMC Plant Biol.
- PubMed:
- 36151520
Brucine, a component of Strychnos nux-vomica with potential anti-tumor and anti-inflammatory effects, is limited by its toxicity, especially in the central nervous system. This study found that brucine induces death in nerve cells and astrocytes, and triggers a pathway involving PPARγ/NF-κB/caspase 3-dependent apoptosis. Brucine directly bound to caspase 3, and a caspase 3 inhibitor abolished the neurotoxicity. These findings provide insight into the toxicity mechanism of brucine and suggest a potential strategy for addressing it.