Stereochemical insights into neuroprotective alkaloids from the aerial parts of Emilia sonchifolia.

Researchers isolated three alkaloids from Emilia sonchifolia plant, including a new compound called emililactam A. They separated two known compounds into their respective enantiomers, and their structures were confirmed using spectroscopic analysis and electronic circular dichroism calculations. In a cell culture study, emililactam A and two other compounds showed moderate neuroprotective effects against corticosterone-induced damage to PC12 cells.

Huang MJ et al (2022).

Fitoterapia.

DOI:

10.1016/j.fitote.2022.105267

PubMed:

35961597

Mussaendoside O, a N-triterpene cycloartane saponin, attenuates RANKL-induced osteoclastogenesis and inhibits lipopolysaccharide-induced bone loss.

Gal M et al (2022).

Phytomedicine.

DOI:

10.1016/j.phymed.2022.154378

PubMed:

35961265

The final piece of the Triangle of U: Evolution of the tetraploid Brassica carinata genome.

Yim WC et al (2022).

Plant Cell.

DOI:

10.1093/plcell/koac249

PubMed:

35961044

Natural remedies for Alzheimer's disease: A systematic review of randomized controlled trials.

Researchers conducted a systematic search to explore natural alternatives for the treatment of Alzheimer's disease (AD), as existing FDA-approved drugs have limitations. They analyzed randomized control trials and found that herbs like Gingko Biloba, Melissa Officinalis, Salvia officinalis, Ginseng, and saffron alone or in combination with curcumin, low-fat diet, NuAD-Trail, and soy lecithin showed significant positive effects on AD. Combining natural remedies with FDA-approved drugs showed more promising results than only using FDA-approved drugs. These findings suggest that herbal remedies could be effective in treating AD.

Ahmad S et al (2023).

Metab Brain Dis.

DOI:

10.1007/s11011-022-01063-9

PubMed:

35960461

Rosmarinus officinalis essential oils from Morocco: new advances on extraction, GC/MS analysis, and antioxidant activity.

Oualdi I et al (2023).

Nat Prod Res.

DOI:

10.1080/14786419.2022.2111561

PubMed:

35959692

Brucea javanica Oil Emulsion Promotes Autophagy in Ovarian Cancer Cells Through the miR-8485/LAMTOR3/mTOR/ATG13 Signaling Axis.

Wang Y et al (2022).

Front Pharmacol.

DOI:

10.3389/fphar.2022.935155

PubMed:

35959437

Characterization of antidepressant activity of Saraca asoca flower (Roxb.) Wilde in mice subjected to acute restraint stress.

Shashikumara S et al (2022).

Am J Transl Res.

PubMed:

35958453

Therapeutic effects of aqueous extract of bioactive active component of Ageratum conyzoides on the ovarian-uterine and hypophysis-gonadal axis in rat with polycystic ovary syndrome: Histomorphometric evaluation and biochemical assessment.

Adelakun SA et al (2022).

Metabol Open.

DOI:

10.1016/j.metop.2022.100201

PubMed:

35958118