GeoBotanical: All Studies

12857.

Jatamansinol from Nardostachys jatamansi Ameliorates Tau-Induced Neurotoxicity in Drosophila Alzheimer's Disease Model.

Jatamansinol, a compound extracted from Nardostachys jatamansi used in traditional medicine, has been found to protect against Tau-induced neurotoxicity in a Drosophila model of Alzheimer's Disease (AD). The study investigated the effects of jatamansinol on lifespan, learning and memory, oxidative stress, and cholinesterase activities in tauopathy flies. Results showed that jatamansinol treatment extended lifespan, improved locomotor activity, enhanced learning and memory, and reduced Tau protein levels while boosting antioxidant enzyme activities and inhibiting cholinesterase activities in Tau-induced AD models. These findings suggest jatamansinol could be a potential therapeutic drug candidate for AD.

Neuroscience Nardostachys jatamansi

Anupama KP et al (2022).; Mol Neurobiol.
DOI:: 10.1007/s12035-022-02964-7
PubMed:: 35864434

12858.

Inhibition of AGEs formation, antioxidative, and cytoprotective activity of Sumac (Rhus typhina L.) tannin under hyperglycemia: molecular and cellular study.

Diabetes Rhus typhina

Sekowski S et al (2023).; Mol Cell Biochem.
DOI:: 10.1007/s11010-022-04522-0
PubMed:: 35861915

12859.

The pyrethroid insecticide permethrin confers hepatotoxicity through DNA damage and mitochondria-associated apoptosis induction in rat: Palliative benefits of Fumaria officinalis.

Genetics Fumaria officinalis

Aoiadni N et al (2022).; J Biochem Mol Toxicol.
DOI:: 10.1002/jbt.23172
PubMed:: 35861702

12860.

α-Asarone alleviates allergic asthma by stabilizing mast cells through inhibition of ERK/JAK2-STAT3 pathway.

Immunology Acorus calamus

Bai H et al (2023).; Biofactors.
DOI:: 10.1002/biof.1879
PubMed:: 35861676

12861.

Transcriptomic analysis of deceptively pollinated Arum maculatum (Araceae) reveals association between terpene synthase expression in floral trap chamber and species-specific pollinator attraction.

Phytochemistry Arum maculatum

Szenteczki MA et al (2022).; G3 (Bethesda).
DOI:: 10.1093/g3journal/jkac175
PubMed:: 35861391

12862.

Protective Effects of Cannabis sativa on chemotherapy-induced nausea in a rat: Involvement of CB1 receptors.

Cancer Cannabis sativa

Elgohary R, Salama A and Omara EA (2023).; Fundam Clin Pharmacol.
DOI:: 10.1111/fcp.12821
PubMed:: 35861135

12863.

Characterization of demethylating DNA glycosylase ROS1 from Nicotiana tabacum L.

Genetics Nicotiana tabacum

Petrova DV et al (2022).; Vavilovskii Zhurnal Genet Selektsii.
DOI:: 10.18699/VJGB-22-41
PubMed:: 35860677

12864.

Explore the Therapeutic Composition and Mechanism of Schisandra chinensis-Acorus tatarinowii Schott on Alzheimer's Disease by Using an Integrated Approach on Chemical Profile, Network Pharmacology, and UPLC-QTOF/MS-Based Metabolomics Analysis.

Researchers investigated the potential of traditional Chinese medicines Schisandra chinensis and Acorus tatarinowii Schott in Alzheimer's disease treatment and found them to have neuroprotective effects. Although the main anti-Alzheimer's compounds and functional mechanisms are unknown, clinical studies have proven their effectiveness. Further research could lead to a better understanding of these traditional medicines and their potential use in treating Alzheimer's disease.

Neuroscience Acorus tatarinowii

Chen J et al (2022).; Oxid Med Cell Longev.
DOI:: 10.1155/2022/6362617
PubMed:: 35860432