Therapeutic and palliative role of a Unani herbal decoction in COVID-19 and similar respiratory viral illnesses: Phytochemical & pharmacological perspective.

Outbreaks of respiratory viruses like SARS, MERS, and COVID-19 have been frequent over the last century, causing many deaths due to complications. Traditional medicines have been observed to offer palliative and therapeutic benefits, including for COVID-19. The Unani herbal decoction, comprising of three fruits/seeds, was originally prescribed for respiratory ailments in the early 1900s and was recently prescribed by the Indian government for mild COVID-19 patients in home isolation. Preliminary studies suggest that the decoction could reduce COVID-19 incidence and severity.

Fazil M and Nikhat S (2022).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2022.115526

PubMed:

35843408

1,2,3,4,6-Pentagalloyl glucose of Pistacia lentiscus can inhibit the replication and transcription processes and viral pathogenesis of SARS-COV-2.

Researchers examined the effects of five active compounds from Pistacia sp. on key targets of the SARS-COV-2 virus. 1,2,3,4,6-pentagalloyl glucose (PG) was found to be the most effective, with strong binding affinities to helicase, RdRp, E protein, and 3CLpro, and was able to inhibit the replication and transcription processes, making it a potential antiviral treatment. The study suggests PG could also have anti-inflammatory and antioxidant properties.

Samandar F et al (2022).

Mol Cell Probes.

DOI:

10.1016/j.mcp.2022.101847

PubMed:

35843391

Molecular networking-based discovery of anti-inflammatory chromene dimers from Melicope pteleifolia.

Kakumu Y, Thi Nguyen MT and Mitsunaga T (2022).

Phytochemistry.

DOI:

10.1016/j.phytochem.2022.113322

PubMed:

35839858

Development of an efficient micropropagation system for Dioscorea bulbifera L. and phytochemical profile of regenerated plants.

Bhat MH et al (2022).

J Genet Eng Biotechnol.

DOI:

10.1186/s43141-022-00382-9

PubMed:

35838925

Development of a validated high-performance thin-layer chromatography method for quantification of lupeol from different parts of Bauhinia acuminata.

Nakkala K and Laddha KS (2022).

Biomed Chromatogr.

DOI:

10.1002/bmc.5448

PubMed:

35837756

The complete chloroplast genome of the medicinal plant Paederia foetida L.

Wang W et al (2022).

Mitochondrial DNA B Resour.

DOI:

10.1080/23802359.2022.2087563

PubMed:

35837498

The complete chloroplast genome sequence of Lespedeza buergeri Miq. (Fabaceae).

Wang S et al (2022).

Mitochondrial DNA B Resour.

DOI:

10.1080/23802359.2022.2093674

PubMed:

35837494

Rosa laevigata Attenuates Allergic Asthma Exacerbated by Water-Soluble PM by Downregulating the MAPK Pathway.

Water-soluble particulate matter (WPM) with heavy metals triggers severe inflammation and worsens asthma. Oral and intratracheal administration of RL reduces inflammation, secretion of cytokines, and IgE, suggesting potential as an asthma treatment.

Ko HM et al (2022).

Front Pharmacol.

DOI:

10.3389/fphar.2022.925502

PubMed:

35837279