Functional Characterization of Genes Coding for Novel β-D-Glucosidases Involved in the Initial Step of Secoiridoid Glucosides Catabolism in Centaurium erythraea Rafn.
- Božunović J et al (2022).
- Front Plant Sci.
- PubMed:
- 35812935
A study investigated five compounds from L. plant and found four new ones. Compound /-rosmarinic acid is four times as active as the single -isomer in inhibiting the 3-chymotrypsin-like protease of the severe acute respiratory syndrome coronavirus 2. Molecular docking and dynamics showed its higher binding affinity for 3CL than the single isomer. The study also revealed the stability of the compounds compared to a reference HIV-1 protease inhibitor. The findings suggest the potential of L. plant compounds as antiviral agents against COVID-19.