GC-MS analysis of phytoconstituents from Ruellia prostrata and Senna tora and identification of potential anti-viral activity against SARS-CoV-2.

Researchers identified natural compounds that can inhibit the activity of the SARS-CoV-2 main protease, which plays a critical role in viral replication. Through computational methods such as molecular docking and simulations, four compounds were identified with good pharmacokinetics and toxicity properties: PubChem CID 70825, CID 25247358, CID 54685836, and CID 1983. Experimental validation is still needed, but these compounds show promise as potential therapeutics for COVID-19.

Alam R et al (2021).

RSC Adv.

DOI:

10.1039/d1ra06842c

PubMed:

35494115

Stellaria media tea protects against diabetes-induced cardiac dysfunction in rats without affecting glucose tolerance.

Demján V et al (2021).

J Tradit Complement Med.

DOI:

10.1016/j.jtcme.2021.08.003

PubMed:

35493309

A review on phytochemical constituents and pharmacological potential of Calotropis procera.

Wadhwani BD et al (2021).

RSC Adv.

DOI:

10.1039/d1ra06703f

PubMed:

35492791

Beneficial interaction between Ficus platyphylla and artesunate on cytokines TNF-α and IL-10 and oxidative stress in Plasmodium berghei-infected mice.

Oraebosi MI et al (2022).

Ann Parasitol.

DOI:

10.17420/ap6801.415

PubMed:

35491857

Modulation of GPCR receptors common to gut inflammatory diseases and neuronal disorders, Alzheimer's and Parkinson's diseases as druggable targets through Withania somnifera bioactives: an in silico study.

The gut microbiota's dysbiosis may lead to neurodegenerative diseases like Alzheimer's and Parkinson's due to increased gut and blood-brain barrier permeability. () is a promising plant for treating neurodegenerative diseases and bowel disorders. The researchers identified five proteins and five best lead compounds after molecular docking analysis and simulation studies, revealing HTR1A and HTR7 proteins with the leads Withanolide E and Withanolide A against them, respectively as the most effective targets. Thus by targeting common potential targets, modulation with bioactive compounds present in can result in effective control of these diseases.

Shukla R et al (2023).

J Biomol Struct Dyn.

DOI:

10.1080/07391102.2022.2068072

PubMed:

35491707

Host and gut microbiome modulate the antiparasitic activity of nectar metabolites in a bumblebee pollinator.

Koch H et al (2022).

Philos Trans R Soc Lond B Biol Sci.

DOI:

10.1098/rstb.2021.0162

PubMed:

35491601

Antispasmodic activity of the ethanol extract of Citrullus lanatus seeds: Justifying ethnomedicinal use in Pakistan to treat asthma and diarrhea.

Citrullus lanatus seeds have been traditionally used in Pakistan, India, and Sudan for treating digestive, respiratory, urinary issues, as well as bedwetting and urinary tract obstruction.

Wahid M et al (2022).

J Ethnopharmacol.

DOI:

10.1016/j.jep.2022.115314

PubMed:

35490899

Systematical characterization and comparison of saponins in Achyranthes bidentata Blume and its three analogous species.

Wang Y et al (2022).

Phytochem Anal.

DOI:

10.1002/pca.3128

PubMed:

35490700